CUL5–ASB6 Complex Promotes p62SQSTM1 Ubiquitination and

p62 com  We found that p62 TRM, but not full-length p62, was involved in nutrient sensing and homeostasis through the mechanistic target of rapamycin complex 1  P62;SQSTM1 Fusion Protein ; Purity, 60%, by SDS-PAGE with Coomassie Brilliant Blue staining ; Formulation, The purified protein was Lyophilized from sterile PBS

Furthermore, SQSTM1p62 also serves as a signaling hub for multiple pathways associated with neurodegeneration, providing a potential The p62 encoding gene was then isolated and termed sequestosome 1 The protein was the first adaptor involved in selective autophagy identified in

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo Synopsis image p62 and ubiquitinated substrates spontaneously coalesce into larger clusters, which result from the crosslinking of p62 filaments by the